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Progesterone during transition

Progesterone is a natural female hormone produced in the second half of the menstrual cycle and during pregnancy by the ovaries and placenta.

Background

Progesterone is a natural female hormone produced in the second half of the menstrual cycle and during pregnancy by the ovaries and placenta. In transgender care it is sometimes added to feminising hormone therapy.

Claims and evidence

Effects on breast formation, libido, mood and sleep are proposed. The Endocrine Society guideline (2017) and the WPATH Standards of Care version 8 (2022) note that the scientific substantiation for these effects is limited and inconclusive. Prescribing is partly based on patient experience.

Risks and considerations

Progesterone can cause fatigue, mood complaints and increased thrombosis risk. When added to estrogen, consultation with the prescribing physician on indication and monitoring is important.