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Genderrisico.nl

Peer-reviewed figures per intervention and per target group — side effects, complications and outcomes of gender care, with source citation.

What Genderrisico.nl documents

Peer-reviewed figures on side effects, complications and outcomes of gender care. Per intervention, per target group, per follow-up duration. No anecdotes, no advocacy — only the figures that emerge from the medical literature, with explicit source citation and methodological qualifications.

Why this is needed

Existing Dutch public information often mentions risks in general terms ('as with any operation') without quantification. Patients cannot thereby estimate how large a specific risk is. Genderrisico fills that in: the percentage of fistulas after vaginoplasty (substantial), the percentage of strictures after phalloplasty-with-urethral-extension (high), cardiovascular incidence with long-term oestrogen use (increased), detransition figures per follow-up duration (growing with time).

How the figures come about

Three criteria:

• Peer-reviewed publication in medical journals;
• Sufficient sample size and follow-up duration — single case reports do not count;
• Methodological assessment: how detransition was defined, how long the follow-up lasted, what selection bias may occur.

Those who find contradictory studies are confronted with the range — not with a forced average. Deliberate uncertainty interval over false precision.

Categories

• Hormonal risks: cardiovascular, hepatic, haematological, bone density, fertility, mental health.
• Surgical complications: per intervention — mastectomy, vaginoplasty, phalloplasty, metoidioplasty, FFS, orchiectomy.
• Regret and detransition: percentages per study, methodological evaluation, long follow-up versus short.
• Mental health pre- and post-transition: depression, anxiety, suicidality, eating disorders — change, not a static picture.
• Paediatric specific: blocker effects on bone density and brain development, progression percentages to cross-sex hormones.

Target audience

Patients and families who want full figures before deciding. Care providers who want to tighten their informed consent protocols. Researchers seeking references. Lawyers working in detransition court cases. Journalists needing accurate figures.

Editorial line

Strictly factual. No preferred interpretation. When one study reports high risks and another low, you get both figures with explanation of why they differ. Those who want to bring methodological criticism are heard; unpublished claims are not adopted.

Place in the network

The figures dossier. Those who arrive via Gender123 or Genderhub and need hard figures end up at Genderrisico. For stories that embody the figures: Genderellende. For current incidents: Gendergekte. For broad explanation: Genderinfo.

What is Genderrisico.nl?

Genderrisico is a dossier site that systematically gathers the medical risks and outcomes of gender care: figures and percentages per intervention, per age group and per outcome measure. Readers receive material to make their own considerations.

What is on it?

The site is built around five main sections:

• Puberty blockers — bone density, brain development, fertility, sexual function and the question of whether the treatment is 'reversible';
• Hormone therapy — cardiovascular risk, thrombosis, cancer risk, liver and metabolic effects;
• Surgical interventions — complication figures for vaginoplasty, phalloplasty, mastectomy and FFS;
• Detransition and regret — prevalence of detransition, regret figures, causes of return;
• Prevalence and research overviews — national and international guidelines, systematic reviews (NICE, SBU, Cass).

For whom?

For patients and families considering a medical pathway, journalists looking for facts, policymakers evaluating guidelines, and care professionals who want to work with evidence. Not intended as a substitute for clinical advice, but as a factual archive.

Tone and approach

Every claim has a DOI or direct URL to the original publication. The site is limited to published research and official bodies. International comparison is a central element: British Cass Review, Swedish Karolinska policy shift, Finnish policy shift and the Cochrane evaluations receive separate attention.

Place within the network

The figures archive of the network. Where this site (Genderinfo.nl) provides broad information, Genderrisico goes into the empirical outcomes of care. For the Dutch care model the site refers to Dutchprotocol.nl; for international guidelines to Wpath.nl.