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Timeline of gender care

The key moments in gender care, from the work of John Money in the 1950s to today's international reorientation.

How the concept of gender came about

Modern thinking about gender begins in 1955. In that year the psychologist John Money in Baltimore first used the word gender for the behaviour and role of men and women, separate from the body. More than ten years later, in 1966, the endocrinologist Harry Benjamin published his book The Transsexual Phenomenon and Johns Hopkins Hospital opened the first American gender clinic at a university.

The Reimer case dates from the same period. On Money's advice, a boy was raised as a girl after a failed circumcision. Money reported a success, but in 1997 it turned out that the boy had never accepted the role of a girl. In 1979 the Harry Benjamin association, later WPATH, drew up the first Standards of Care. In the same year Johns Hopkins stopped performing sex reassignment surgery after a critical study. A year later the American manual of psychiatry for the first time included diagnoses for transsexualism and for gender identity disorder in children: the DSM-III.

The Netherlands: from Amsterdam to the Dutch Protocol

In the Netherlands gender care was given a permanent place around 1975 with the gender team of the Vrije Universiteit in Amsterdam, which grew into one of the largest and most influential gender centres in the world. Since 1 August 1985 the court has been able to change the sex recorded on the birth certificate, at that time on condition of physical adaptation and permanent infertility.

The medical treatment of young people began in the Netherlands. In 1987 the first European outpatient clinic for children and young people with gender problems opened in Utrecht. In 1998 Cohen-Kettenis and Van Goozen described the first young person whose puberty had been suppressed with medication. In 2006 the publication of the full treatment model followed: puberty blockers from the age of twelve, hormones from sixteen and surgery from eighteen. That model became known as the Dutch Protocol.

The Amsterdam group supported the model with two studies. The first outcome study from 2011 described seventy young people during treatment with puberty blockers: depressive symptoms decreased, the gender dysphoria itself did not change. The follow-up study from 2014 described 55 young adults after blockers, hormones and surgery and became the most cited evidence for the protocol.

The model spreads across the world

In 2009 the Endocrine Society, the international association of endocrinologists, included puberty suppression in its first guideline. With that, the Dutch Protocol became worldwide practice. In 2013 the DSM-5 replaced the diagnosis gender identity disorder with gender dysphoria. In the Netherlands, on 1 July 2014 the Transgender Act abolished the requirement of surgery or infertility for changing the registered sex; since then an expert statement has been sufficient, from the age of sixteen. In 2019 the Netherlands got its own national standard, the Kwaliteitsstandaard Transgenderzorg Somatisch, which follows the Dutch Protocol.

The turning point from 2018

From 2018 the model came under pressure. In that year Lisa Littman described in PLOS ONE a pattern of rapid-onset gender dysphoria in adolescents, a publication that was followed by a fierce methodological debate. In 2020 Finland made psychosocial support the first step, and the British court ruled in Bell v Tavistock that young people under sixteen are unlikely to be able to consent to puberty blockers. That ruling was overturned on appeal in 2021.

After that the assessments followed one another quickly. In 2021 the British institute NICE rated the evidence for blockers and hormones in minors as of very low certainty. In 2022 the Swedish health authority concluded that the risks outweigh the benefits, NHS England announced the closure of the Tavistock gender clinic and version 8 of the WPATH guideline appeared, from which the minimum ages were removed shortly after publication. In 2023 the Norwegian investigation board Ukom advised revising the national guideline.

In 2024 the Cass Review appeared, the final report of four years of research led by Hilary Cass. Later that year the British government made the ban on puberty blockers for minors with gender dysphoria permanent. In 2025 the US Department of Health and Human Services published its own critical assessment and the US Supreme Court ruled that states may ban this treatment for minors.

Where the Netherlands stands now

So far the Netherlands has held on to the existing care. In 2024 the House of Representatives asked for research into the outcomes of the Dutch treatment of young people, after which the ministry asked the Health Council for advice. In 2026 the Health Council advised the minister that Dutch care for young people is carefully organised. You can read the background under Dutch developments.

How to read the timeline

The timeline lists the moments that shaped this course of events, from old to new. Each moment has its own page with an explanation and the sources on which the text is based. What other countries have decided is set out per country under policy by country and under international developments. The reports and studies themselves can be found in the archive, and the substantive discussion under science and debate.

All moments

1955

John Money introduces the concept of gender role

Sexologist John Money (right) sits on a bench in Rome in 1996 next to Romano Forleo and his wife.

In Baltimore, psychologist John Money is the first to use the word gender to describe the behavior and roles of men and women, separate from the body. This marks the beginning of modern thinking about gender.

Read more →

1966

Harry Benjamin and the First American Gender Clinic

Black-and-white portrait of the young physician Harry Benjamin, seated in a room in New York in 1913.

Endocrinologist Harry Benjamin publishes The Transsexual Phenomenon. That same year, Johns Hopkins Hospital opens the first gender clinic at an American university.

Read more →

1967

The Reimer Case

The William H. Welch Medical Library of the Johns Hopkins University School of Medicine in Baltimore

On John Money’s advice, a boy was raised as a girl after a botched circumcision. Money reported success; in 1997, it became clear that the boy had never accepted the female role.

Read more →

1975

Gender care takes root at VU Amsterdam

Black-and-white photo from 1970 of the VU Hospital in Amsterdam-Buitenveldert, with construction cranes and parked cars.

Around 1975, the Vrije Universiteit hospital in Amsterdam established a gender team. It grew into one of the largest and most influential gender centres in the world.

Read more →

1979

First Standards of Care; Johns Hopkins Stops Performing Surgeries

The historic buildings of Johns Hopkins Hospital in Baltimore, seen from the entrance gate

The newly established Harry Benjamin Association, later known as WPATH, drew up the first international guidelines. That same year, Johns Hopkins stopped performing gender-affirming surgeries following a critical study.

Read more →

1980

DSM-III: transsexualism becomes a psychiatric diagnosis

Title page of the French translation of the American Psychiatric Association’s DSM-III

The American psychiatric manual includes diagnoses for transsexualism in adults and gender identity disorder in children for the first time.

Read more →

1985

The Netherlands makes it possible to change the sex recorded on a birth certificate

The Binnenhof in The Hague with the Hofvijver pond in the foreground

Since 1 August 1985, a court has been able to change the gender recorded on a birth certificate. The requirements are physical adaptation and permanent infertility.

Read more →

1987

The Beginning of Gender Care for Young People in the Netherlands

UMC Utrecht on Heidelberglaan

The first European clinic for children and young people with gender-related issues opens in Utrecht — laying the foundation for what would later become known as the Dutch Protocol.

Read more →

1998

First Publication on Puberty Suppression

The outpatient clinic building of VU Medical Center in Amsterdam

Cohen-Kettenis and Van Goozen describe the first young person whose puberty was suppressed with medication while awaiting further treatment.

Read more →

2006

The Dutch Protocol Is Published

Outpatient clinic building of VU University Medical Center in Amsterdam, with people waiting at the tram stop in front of it.

Delemarre-van de Waal and Cohen-Kettenis describe the complete treatment model: puberty blockers from age twelve, hormones from age sixteen, and surgery from age eighteen.

Read more →

2009

Endocrine Society includes puberty suppression in its guideline

The entrance to the Endocrine Society’s office building in Washington

The first guideline issued by the international association of endocrinologists recommends puberty blockers for young people with gender dysphoria. The Dutch Protocol thus becomes standard practice worldwide.

Read more →

2011

First Outcome Study of the Dutch Protocol

The O|2 Lab building of VU Amsterdam and Amsterdam UMC on De Boelelaan in Amsterdam

The Amsterdam group describes seventy young people undergoing treatment with puberty blockers. Depressive symptoms decrease; gender dysphoria itself does not change.

Read more →

2013

DSM-5: gender dysphoria replaces disorder

The DSM-5 manual on a copy of the French DSM-IV-TR

The American psychiatric classification system replaced “gender identity disorder” with “gender dysphoria” — a less stigmatizing term focused on the distress itself.

Read more →

2014

Transgender Act: Sterilisation Requirement Abolished

Empty plenary chamber of the Senate with green benches, red carpet and a painted ceiling.

Since 1 July 2014, surgery or infertility is no longer required to change gender registration. A statement from an expert is sufficient from the age of sixteen.

Read more →

2014

Follow-up study: outcomes after hormones and surgery

The northwest wing of the VUmc complex on De Boelelaan in Amsterdam

The Amsterdam group describes 55 young adults after puberty blockers, hormones, and surgery. The study is the most frequently cited evidence for the Dutch Protocol.

Read more →

2018

Littman publishes ROGD paper

Brick buildings on the Brown University campus

In PLOS ONE, Lisa Littman describes a pattern of rapid-onset gender dysphoria in adolescents—a subject of intense methodological debate.

Read more →

2019

Somatic Transgender Healthcare Quality Standard

The main entrance of Radboudumc in Nijmegen, still called UMC St Radboud in 2009

The Netherlands is getting its own national standard for medical transgender care, including a module on children and young people. The standard follows the Dutch Protocol.

Read more →

2020

Finland opts for restraint

The main entrance of Tampere University Hospital (Tays) in Finland

Finland’s Council for Choices in Health Care makes psychosocial support the first step. Hormonal treatment for minors is now only available after an individual assessment at one of two university hospitals.

Read more →

2020

Bell v Tavistock

The Royal Courts of Justice in London

The British court ruled that young people under sixteen are probably unable to consent to puberty blockers. On appeal, that ruling was overturned in 2021.

Read more →

2021

NICE assesses the evidence for puberty blockers and hormones

The City Tower office building at Piccadilly Plaza in Manchester

The UK institute NICE concludes that the evidence for puberty blockers and hormones in minors is of very low certainty. This finding carries significant weight in the Cass Review.

Read more →

2022

Sweden Restricts Hormonal Treatment for Minors

The main entrance of Karolinska University Hospital in Huddinge

The Swedish health authority, the National Board of Health and Welfare, concludes that the risks of puberty blockers and hormones for minors outweigh the benefits. Treatment remains an exception.

Read more →

2022

Closure of the Tavistock Gender Clinic Announced

The Tavistock Centre in London behind bare trees, with a statue of Sigmund Freud in the foreground.

Following Hilary Cass’s interim report, NHS England decided to close England’s only gender clinic for young people and replace it with regional centres.

Read more →

2022

WPATH Standards of Care Version 8

A stethoscope next to a laptop on which someone is typing

The global guideline for transgender healthcare is being updated. Minimum ages for treatments were removed shortly after publication—a decision criticized for its lack of supporting evidence.

Read more →

2023

Norwegian Investigation Board Recommends Caution

Rikshospitalet at Oslo University Hospital

The Norwegian Healthcare Investigation Board, Ukom, concludes that the evidence base for treating minors is insufficient and recommends revising the national guideline.

Read more →

2024

Dutch House of Representatives Calls for Research into the Dutch Protocol

Empty plenary chamber of the Dutch House of Representatives at its temporary location, with rows of blue seats.

The Dutch House of Representatives wants the outcomes of treatment for young people in the Netherlands to be investigated. In response, the ministry asked the Health Council for advice.

Read more →

2024

The Cass Review Is Published

Portrait of Hilary Cass, the pediatrician who led the Cass Review

British pediatrician Hilary Cass publishes four years of research: the evidence base for puberty blockers and hormones in young people is weak. NHS England stops prescribing them routinely.

Read more →

2024

United Kingdom bans puberty blockers indefinitely

The Palace of Westminster with the Elizabeth Tower in London, viewed across the River Thames

The UK government is making the ban on prescribing puberty blockers to minors with gender dysphoria permanent. Treatment will only be available as part of research.

Read more →

2025

U.S. Department Assesses the Evidence

Concrete Hubert H. Humphrey Building in Washington, D.C., headquarters of the U.S. Department of Health and Human Services.

The U.S. Department of Health and Human Services has published its own assessment of treatment for minors. The report is critical and advocates psychotherapy as the first step.

Read more →

2025

U.S. Supreme Court: States May Ban Treatment

The United States Supreme Court building in Washington

In United States v. Skrmetti, the Supreme Court ruled that Tennessee may ban puberty blockers and hormones for minors with gender dysphoria.

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2026

Health Council: transgender care for young people is carefully organised

Orange-red office building De Resident on Parnassusplein in The Hague, viewed from below.

The Health Council advises the minister that healthcare for young people in the Netherlands is carefully structured. The Netherlands is therefore maintaining its existing approach to treatment.

Read more →