Timeline of gender care
The key moments in gender care, from the work of John Money in the 1950s to today's international reorientation.
How the concept of gender came about
Modern thinking about gender begins in 1955. In that year the psychologist John Money in Baltimore first used the word gender for the behaviour and role of men and women, separate from the body. More than ten years later, in 1966, the endocrinologist Harry Benjamin published his book The Transsexual Phenomenon and Johns Hopkins Hospital opened the first American gender clinic at a university.
The Reimer case dates from the same period. On Money's advice, a boy was raised as a girl after a failed circumcision. Money reported a success, but in 1997 it turned out that the boy had never accepted the role of a girl. In 1979 the Harry Benjamin association, later WPATH, drew up the first Standards of Care. In the same year Johns Hopkins stopped performing sex reassignment surgery after a critical study. A year later the American manual of psychiatry for the first time included diagnoses for transsexualism and for gender identity disorder in children: the DSM-III.
The Netherlands: from Amsterdam to the Dutch Protocol
In the Netherlands gender care was given a permanent place around 1975 with the gender team of the Vrije Universiteit in Amsterdam, which grew into one of the largest and most influential gender centres in the world. Since 1 August 1985 the court has been able to change the sex recorded on the birth certificate, at that time on condition of physical adaptation and permanent infertility.
The medical treatment of young people began in the Netherlands. In 1987 the first European outpatient clinic for children and young people with gender problems opened in Utrecht. In 1998 Cohen-Kettenis and Van Goozen described the first young person whose puberty had been suppressed with medication. In 2006 the publication of the full treatment model followed: puberty blockers from the age of twelve, hormones from sixteen and surgery from eighteen. That model became known as the Dutch Protocol.
The Amsterdam group supported the model with two studies. The first outcome study from 2011 described seventy young people during treatment with puberty blockers: depressive symptoms decreased, the gender dysphoria itself did not change. The follow-up study from 2014 described 55 young adults after blockers, hormones and surgery and became the most cited evidence for the protocol.
The model spreads across the world
In 2009 the Endocrine Society, the international association of endocrinologists, included puberty suppression in its first guideline. With that, the Dutch Protocol became worldwide practice. In 2013 the DSM-5 replaced the diagnosis gender identity disorder with gender dysphoria. In the Netherlands, on 1 July 2014 the Transgender Act abolished the requirement of surgery or infertility for changing the registered sex; since then an expert statement has been sufficient, from the age of sixteen. In 2019 the Netherlands got its own national standard, the Kwaliteitsstandaard Transgenderzorg Somatisch, which follows the Dutch Protocol.
The turning point from 2018
From 2018 the model came under pressure. In that year Lisa Littman described in PLOS ONE a pattern of rapid-onset gender dysphoria in adolescents, a publication that was followed by a fierce methodological debate. In 2020 Finland made psychosocial support the first step, and the British court ruled in Bell v Tavistock that young people under sixteen are unlikely to be able to consent to puberty blockers. That ruling was overturned on appeal in 2021.
After that the assessments followed one another quickly. In 2021 the British institute NICE rated the evidence for blockers and hormones in minors as of very low certainty. In 2022 the Swedish health authority concluded that the risks outweigh the benefits, NHS England announced the closure of the Tavistock gender clinic and version 8 of the WPATH guideline appeared, from which the minimum ages were removed shortly after publication. In 2023 the Norwegian investigation board Ukom advised revising the national guideline.
In 2024 the Cass Review appeared, the final report of four years of research led by Hilary Cass. Later that year the British government made the ban on puberty blockers for minors with gender dysphoria permanent. In 2025 the US Department of Health and Human Services published its own critical assessment and the US Supreme Court ruled that states may ban this treatment for minors.
Where the Netherlands stands now
So far the Netherlands has held on to the existing care. In 2024 the House of Representatives asked for research into the outcomes of the Dutch treatment of young people, after which the ministry asked the Health Council for advice. In 2026 the Health Council advised the minister that Dutch care for young people is carefully organised. You can read the background under Dutch developments.
How to read the timeline
The timeline lists the moments that shaped this course of events, from old to new. Each moment has its own page with an explanation and the sources on which the text is based. What other countries have decided is set out per country under policy by country and under international developments. The reports and studies themselves can be found in the archive, and the substantive discussion under science and debate.
All moments
1955
John Money introduces the concept of gender role

In Baltimore, psychologist John Money is the first to use the word gender to describe the behavior and roles of men and women, separate from the body. This marks the beginning of modern thinking about gender.
1966
Harry Benjamin and the First American Gender Clinic

Endocrinologist Harry Benjamin publishes The Transsexual Phenomenon. That same year, Johns Hopkins Hospital opens the first gender clinic at an American university.
1967
The Reimer Case

On John Money’s advice, a boy was raised as a girl after a botched circumcision. Money reported success; in 1997, it became clear that the boy had never accepted the female role.
1975
Gender care takes root at VU Amsterdam

Around 1975, the Vrije Universiteit hospital in Amsterdam established a gender team. It grew into one of the largest and most influential gender centres in the world.
1979
First Standards of Care; Johns Hopkins Stops Performing Surgeries

The newly established Harry Benjamin Association, later known as WPATH, drew up the first international guidelines. That same year, Johns Hopkins stopped performing gender-affirming surgeries following a critical study.
1980
DSM-III: transsexualism becomes a psychiatric diagnosis

The American psychiatric manual includes diagnoses for transsexualism in adults and gender identity disorder in children for the first time.
1985
The Netherlands makes it possible to change the sex recorded on a birth certificate

Since 1 August 1985, a court has been able to change the gender recorded on a birth certificate. The requirements are physical adaptation and permanent infertility.
1987
The Beginning of Gender Care for Young People in the Netherlands

The first European clinic for children and young people with gender-related issues opens in Utrecht — laying the foundation for what would later become known as the Dutch Protocol.
1998
First Publication on Puberty Suppression

Cohen-Kettenis and Van Goozen describe the first young person whose puberty was suppressed with medication while awaiting further treatment.
2006
The Dutch Protocol Is Published

Delemarre-van de Waal and Cohen-Kettenis describe the complete treatment model: puberty blockers from age twelve, hormones from age sixteen, and surgery from age eighteen.
2009
Endocrine Society includes puberty suppression in its guideline

The first guideline issued by the international association of endocrinologists recommends puberty blockers for young people with gender dysphoria. The Dutch Protocol thus becomes standard practice worldwide.
2011
First Outcome Study of the Dutch Protocol

The Amsterdam group describes seventy young people undergoing treatment with puberty blockers. Depressive symptoms decrease; gender dysphoria itself does not change.
2013
DSM-5: gender dysphoria replaces disorder

The American psychiatric classification system replaced “gender identity disorder” with “gender dysphoria” — a less stigmatizing term focused on the distress itself.
2014
Transgender Act: Sterilisation Requirement Abolished

Since 1 July 2014, surgery or infertility is no longer required to change gender registration. A statement from an expert is sufficient from the age of sixteen.
2014
Follow-up study: outcomes after hormones and surgery

The Amsterdam group describes 55 young adults after puberty blockers, hormones, and surgery. The study is the most frequently cited evidence for the Dutch Protocol.
2018
Littman publishes ROGD paper

In PLOS ONE, Lisa Littman describes a pattern of rapid-onset gender dysphoria in adolescents—a subject of intense methodological debate.
2019
Somatic Transgender Healthcare Quality Standard

The Netherlands is getting its own national standard for medical transgender care, including a module on children and young people. The standard follows the Dutch Protocol.
2020
Finland opts for restraint

Finland’s Council for Choices in Health Care makes psychosocial support the first step. Hormonal treatment for minors is now only available after an individual assessment at one of two university hospitals.
2020
Bell v Tavistock

The British court ruled that young people under sixteen are probably unable to consent to puberty blockers. On appeal, that ruling was overturned in 2021.
2021
NICE assesses the evidence for puberty blockers and hormones

The UK institute NICE concludes that the evidence for puberty blockers and hormones in minors is of very low certainty. This finding carries significant weight in the Cass Review.
2022
Sweden Restricts Hormonal Treatment for Minors

The Swedish health authority, the National Board of Health and Welfare, concludes that the risks of puberty blockers and hormones for minors outweigh the benefits. Treatment remains an exception.
2022
Closure of the Tavistock Gender Clinic Announced

Following Hilary Cass’s interim report, NHS England decided to close England’s only gender clinic for young people and replace it with regional centres.
2022
WPATH Standards of Care Version 8

The global guideline for transgender healthcare is being updated. Minimum ages for treatments were removed shortly after publication—a decision criticized for its lack of supporting evidence.
2023
Norwegian Investigation Board Recommends Caution

The Norwegian Healthcare Investigation Board, Ukom, concludes that the evidence base for treating minors is insufficient and recommends revising the national guideline.
2024
Dutch House of Representatives Calls for Research into the Dutch Protocol

The Dutch House of Representatives wants the outcomes of treatment for young people in the Netherlands to be investigated. In response, the ministry asked the Health Council for advice.
2024
The Cass Review Is Published

British pediatrician Hilary Cass publishes four years of research: the evidence base for puberty blockers and hormones in young people is weak. NHS England stops prescribing them routinely.
2024
United Kingdom bans puberty blockers indefinitely

The UK government is making the ban on prescribing puberty blockers to minors with gender dysphoria permanent. Treatment will only be available as part of research.
2025
U.S. Department Assesses the Evidence

The U.S. Department of Health and Human Services has published its own assessment of treatment for minors. The report is critical and advocates psychotherapy as the first step.
2025
U.S. Supreme Court: States May Ban Treatment

In United States v. Skrmetti, the Supreme Court ruled that Tennessee may ban puberty blockers and hormones for minors with gender dysphoria.
2026
Health Council: transgender care for young people is carefully organised

The Health Council advises the minister that healthcare for young people in the Netherlands is carefully structured. The Netherlands is therefore maintaining its existing approach to treatment.