dutchprotocol.nl
dutchprotocol.nl describes itself as a critical research dossier on the VUmc protocol for adolescent care, based on publicly available sources. It focuses on the treatment approach involving puberty blockers and hormones that was developed in the Netherlands and subsequently adopted in many countries.
The main article on this subject is Dutchprotocol.nl.
The site is published by Stichting Genderinfo i.o. and explicitly states that it is not affiliated with Amsterdam UMC, Vrije Universiteit, the Ministry of Health, Welfare and Sport, or any other government or academic institution. The site belongs to the same network as genderinfo.nl. That network also includes puberteitsremmers.nl, a dossier on the drugs themselves.
What you will find
The dossier is organized into fixed sections: the protocol itself, the studies and scientific basis, its international application, evaluations and reviews, debate and criticism, and documents and sources. There are also sections on funding and legal liability. Reference pages such as an FAQ, a timeline, a people directory, and a glossary make the material searchable. Parents, healthcare providers, and journalists each have their own dedicated entry point.
Key points of the dossier
The homepage summarizes the criticism in several figures. The dossier points out that the best-known outcome study, the 2014 study by De Vries, followed 55 adolescents; that there are no randomized controlled trials; and that the strength of the evidence was rated as very low according to the GRADE methodology. The site also states that 96 to 98 percent of young people continue with sex hormones after taking puberty blockers. The dossier describes the scientific basis as a handful of publications from a single research group, without a control group. In its evaluation section, the site discusses the Cass Review and assessments by Sweden's SBU, Finland's COHERE, the UK's NICE, and Norway's Ukom. A section on the financial model estimates direct healthcare costs at 40 to 60 million euros per year.
Current articles
Alongside the permanent dossier, the site publishes articles on new developments. Recent pieces discuss a publication by Amsterdam-based researchers associated with Annelou de Vries, a contribution by Mia Hughes of Genspect on early transgender care in the Netherlands, and parliamentary questions submitted by Diederik van Dijk (SGP) in June 2026. The site takes an explicitly critical tone. Readers who want to assess its claims can compare the articles with the systematic reviews and the timeline on this site.
Why it is included in this archive
After reading the introduction to the Dutch Protocol on this site, anyone who wants to examine the underlying studies and international evaluations, such as the Cass Review, in detail can find them in the more extensive dossier.